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For other inquiries, please contact:
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nPOD@pathology.ufl.edu
POD Scientific Investigators (updated August 6, 2010)
| Category | Investigator | Institution | Grant Title |
|---|---|---|---|
| Beta Cell Regeneration | Mark Atkinson & Patrick Rowe | University of Florida | The ductal pancreatic progenitor microenvironment in type 1 diabetes |
| Dieter Egli, Ruddy Leibel & Scott Noggle | Columbia University | Generation of pluripotent stem cells from diabetics | |
| Leonard Harrison | The Walter & Eliza Hall Institute of Medical Research | Evidence for increased numbers of stem cells in human T1D pancreas | |
| Matthias Hebrok | University of California, San Francisco | Investigating the de-differentiated state of the ß-cell in human diabetic patient tissues | |
| Jake Kushner | University of Pennsylvania | Do de-granulated ß-cells persist in type 1 diabetes? | |
| Douglas Melton | Harvard University | Generation of tools to distinguish human pancreatic cell populations | |
| Christopher Rhodes | University of Chicago | "Empty Beta Cells" in type 1 diabetes | |
| Immunology | Mark Stuart Anderson | University of California, San Francisco | Identification of extrathymic Aire-expressing cells in human lymph nodes |
| Manuela Battaglia & Ezio Bonifacio | San Raffaele Scientific Institute | Dissecting the effector/regulatory compartments in the target tissues of T1D | |
| Howard Davidson | University of Colorado Health Science Center | Autoantigen-specific PLN T-cell receptors | |
| Garry Fathman | Stanford University | Microarray analysis of PLN from autoantibody positive donors | |
| Dale Greiner | University of Massachusetts |
Diabetogenic function of nPOD donor splenocytes in humanized mice | |
| Dolores Jaraquemada | Universitat Autonoma de Barcelona | Tracing effector and regulatory T-cell populations in type 1 diabetes | |
| Sally Kent | University of Massachusetts Medical Center | T-cells in human islets and PLN | |
| Richard David Leslie | University of London | Risk of autoimmune disease and human self-antigen expression | |
| Maki Nakayama & Joe Larkin, III | University of Colorado & University of Florida | TCR utilization in type 1 diabetes insulitis | |
| Jerry Nepom | Benaroya Research Institute at Virginia Mason | TCR repertoire analysis in type 1 diabetes | |
| Alberto Pugliese | Diabetes Research Institute, University of Miami | Beta cells and autoimmunity correlations | |
| Helena Reijonen | Benaroya Research Institute at Virginia Mason | TCR repertoire analysis in type 1 diabetes | |
| Bart Roep | Leiden University | Detection of islet autoreactive CD8 T-cells in insulitis versus periphery | |
| Suparna Sarkar & Dirk Homann | University of Colorado, Denver | Pancreatic expression of chemokines in human type 1 diabetes | |
| Jo Spencer | King's College London School of Medicine | Phenotype, specificity, diversity and clonal spread of ß-cells in type 1 diabetes | |
| Matthias von Herrath | University of California, San Diego | Tetramer staining of pre-diabetic pancreata MHC | |
| Garth Warnock | University of British Columbia | Characterization of T-cell costimulatory molecules in pancreata from IAPCD | |
| Clive Wasserfall & Mark Pescovitz | University of Florida & Indiana University | Humoral immunity in type 1 diabetes | |
| Metabolic and Developmental | Decio Eizirik & Ihsane Marhfour | Univeristè Libre de Bruxelles | Characterization of beta cell ER stress markers in type 1 diabetes |
| Ivan Gerling | University of Tennessee, Memphis | Sequencing the islet transcriptome | |
| Kevan Herold & Alfred Bothwell | Yale University | Reconstruction of HHLS mice with bone marrow from patients with T1DM | |
| Ruddy Leibel & Nao Wakae | Columbia University | E-cadherin mediates developmental effects on the proliferation and the function of ß-cells in the islet of Langerhans | |
| Clayton Mathews | University of Florida | Islet resistance to T1D | |
| Sara Michie & Baohui Xu | Stanford University | Tissue-selective chemokines and adhesion molecules in human type 1 diabetes | |
| Jerry Nadler, Margaret Morris & Kaiwen Ma | Eastern Virginia Medical School | 12/15 Lipoxygenase expression in type 1 diabetes | |
| Al Powers | Vanderbilt University | Islet biology and vascularization | |
| Charmaine Simeonovic | Australian National University | Heparan sulfate levels mark the health status of human islet ß-cells | |
| Gerald Taborsky, Jr. | University of Washington | Sympathetic neuropathy in type 1 diabetes | |
| Pathology | Jeffrey Bluestone & Armando Villalta | University of California, San Francisco | Vascular endothelial growth factor receptor signaling regulates the pathogenesis of diabetes mellitus type 1 |
| Martha Campbell-Thompson & Mark Atkinson | University of Florida | Pancreatic immunologic and metabolic parameters | |
| Roberto Gianani & Mark Atkinson | University of Colorado & University of Florida | Histopathology of type 1 diabetes | |
| Akihisa Imagawa & Toshiaki Hanafusa | Osaka University | Histological differences between Japanese and Western type 1 diabetes | |
| George King & Susan Bonner-Weir | Harvard University | Joslin Medalist Study | |
| Paolo Maddedu & Costanza Emanueli | University of Bristol | Microangiopathy in diabetic bone marrow | |
| Brad Marsh | University of Queensland | 3D characterization of islet dysfunction/destruction | |
Lydia Sorokin & |
University of Muenster | Peri-capsular basement membrane degradation during leukocyte penetration into the pancreatic islet during development of human T1D | |
| Ranjeny Thomas | University of Queensland | Pathological changes associated with chronic Re1B activation in T1D | |
| Thomas Wight | Benaroya Research Institute at Virginia Mason | Extracellular matrix involvement in type 1 diabetes pancreatic destruction | |
| Type 1 Diabetes Etiology | Heikki Hyoty | University of Tampere | Virus detection in pancreas and other tissues |
| Ake Sjoholm | Karolinska Institute | Ljungan virus in type 1 diabetes | |
| John Todd, Vincent Plagnol & Herbert Virgin, IV | University of Cambridge, University College London & Washinton University | Characterization of the nPOD samples virome by high throughput DNA sequencing | |
| Steven Tracy | University of Nebraska | Enteroviral infection and type 1 diabetes | |
| Eric Triplett & Martha Campbell-Thompson | University of Florida | Gut microbiota in early type 1 diabetes |